In Seattle, an increasing number of gonorrhea infections in men who have sex with men have demonstrated reduced susceptibility to azithromycin — one of two drugs recommended to treat the increasingly drug-resistant STD.

Date: Oct 17, 2017

Source: Healio

Via: Barbee LA, et al. Clin Infect Dis. 2017;doi:10.1093/cid/cix898.

Excerpt:

According to researchers from the Seattle and King County public health department, the CDC has set an azithromycin “alert value” minimum inhibitory concentration (MIC) level of 2 µg/mlL or greater for Neisseria gonorrhea.

WHO and the CDC recommend single doses of intramuscular ceftriaxone (250 mg) and oral azithromycin (1 g) to treat gonorrhea, but both also recommend removing an antimicrobial from treatment when more than 5% of circulating isolates are resistant to the drug or it becomes less than 95% effective. Between 2014 and 2016, 5% of gonorrhea cases identified in MSM in Seattle had azithromycin alert-value MICs, the researchers reported.

Link: https://www.healio.com/infectious-disease/stds/news/in-the-journals/%7B4e41dcf3-0a6a-4d26-9c32-7e5fbc77b72c%7D/gonorrhea-resistance-to-azm-reaches-5-threshold-among-seattle-msm